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2026.02.28

Reprinted: Expert Consensus on the Comprehensive Diagnosis and Treatment of Peritoneal Metastasis from Appendiceal Epithelial Tumors (2025 Edition)


Appendiceal epithelial tumors refer to neoplastic lesions originating from the mucosal epithelium of the appendix. These tumors exhibit marked heterogeneity in their pathological features and biological behavior. Due to their unique structural and biological characteristics, they have a high propensity for peritoneal metastasis. Currently, there is limited evidence-based medical support for the diagnosis and treatment of appendiceal epithelial tumors and their peritoneal metastases, and clinical practice still lacks unified guidelines. To address this gap, the Specialist Committee on Integrated Rehabilitation for Peritoneal Tumors of the Chinese Anti-Cancer Association has brought together multidisciplinary experts to systematically integrate specialized technical expertise around key aspects including pathological classification and clinical staging of appendiceal epithelial tumors, indications for extended resection following local excision, surgical strategies for managing concurrent peritoneal metastases, perioperative rehabilitation, and personalized treatment approaches. At the same time, the committee has standardized the perioperative management of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC), as well as the clinical application of prehabilitation protocols, thereby enhancing the practicality and operability of these procedures. Ultimately, the "Expert Consensus on Comprehensive Diagnosis and Treatment of Peritoneal Metastasis from Appendiceal Epithelial Tumors (2025 Edition)" has been developed. This consensus aims to further standardize the systematic diagnostic and therapeutic workflows for appendiceal epithelial tumors, reduce the risk of recurrence, improve patient outcomes, and promote the standardization and homogenization of the diagnosis and treatment of peritoneal metastases from these tumors.

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